New 3D-Printed Nasal Swab for COVID-19 Testing

April 22, 2020

Markforged announced that it is partnering with Neurophotometrics to produce Fiberflex Rayon, 3D-printed nasopharyngeal (NP) swabs for use in diagnostic testing for COVID-19. Reportedly, the new 3D-printed swabs successfully detected the virus in all of the patients, while the commercial swabs reported false negatives. The team is currently producing 10,000 swabs/day, with plans to scale to 100,000/day.

“Identifying COVID-19 infected patients is the best way to slow down the spread of the disease, but we’re seeing a lot of issues with wide-scale testing,” says Greg Mark, CEO and founder of Markforged, which has undertaken a number of COVID-19 initiatives. “There are massive shortages of nasal swabs and to make matters worse, hospitals are reporting false negatives with the current swabs on the market.”

In a collaborative effort by the San Diego Covid Research Enterprise Network (SCREEN) Initiative — a group of scientists, students, research institutions, and others in the San Diego area — Neurophotometrics, Rady Children’s Hospital-San Diego, the Scripps Research Institute and the University of California San Diego designed and tested the swabs with 50 volunteers. Patients confirmed to be positive for COVID-19 were re-tested three to 14 days later with both a commercial swab and the 3D-printed swab. Testing with the commercial swab detected the virus in most, but not all of the patients, while all of the 3D-printed swabs came back positive, suggesting that the 3D-printed swab may be more efficient at collecting viral particles and may reduce the rate of false negatives.

The 3D-printed design couples a 3D-printed nylon swab base with a wrapped rayon tip to gather the viral specimens. The nasopharyngeal swabs must be both flexible enough to enter the nasal cavity and strong enough to withstand significant mechanical force or torsion without breaking or shearing. The 3D-printed swab has been evaluated in testing to ensure it meets the mechanical demands of clinical use and assessed to be comparable to the mechanical performance of commercial swabs.

“Neurophotometrics collaborated with Markforged and medical professionals to scale this 3D printed swab at a rapid pace,” says Sage Aronson, CEO and Founder of Neurophotometrics. “Markforged 3D printing enabled us to test more than 50 prototypes in 36 hours. We’ve turned an idea into a viable product that’s going to save lives.”

 

See also: Markforged

Technologies: Applications, Non-Powder Metals

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